Document Detail

The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients.
MedLine Citation:
PMID:  12821775     Owner:  NLM     Status:  MEDLINE    
Injection of neonatal bone marrow cells from mice lacking the gene encoding suppressor of cytokine signaling 1 (SOCS1) into irradiated syngeneic 129/Sv or C57BL/6 mice led to a decreased survival, more rapidly occurring in 129/Sv than in C57BL/6 mice. Moribund mice did not exhibit the acute or chronic diseases developed by Socs1-/- mice but developed a pathology characteristic of graft-versus-host disease with typical chronic inflammatory lesions in the liver, skin, lungs, and gut. The results indicate that cells derived from the Socs1-/- bone marrow are autoaggressive but did not identify the cell types involved. Failure of the engrafted Socs1-/- marrow cells to reproduce the tissue damage typical of Socs1-/- disease indicates that loss of SOCS1 from target tissues may also be required for the development of the Socs1-/- diseases, such as fatty degeneration of the liver, polymyositis, or corneal inflammation.
Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Warren S Alexander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-06-23
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  100     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-09-04     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8436-41     Citation Subset:  IM    
Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia.
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MeSH Terms
Bone Marrow Transplantation*
Carrier Proteins / genetics,  physiology*
Cytokines / physiology
Genes, Lethal
Graft vs Host Disease
Interferon-gamma / physiology
Intestines / pathology
Kidney / pathology
Liver / pathology
Lung / pathology
Lymphoid Tissue / pathology
Mice, Inbred C57BL
Mice, Knockout
Myocardium / pathology
Radiation Chimera
Repressor Proteins*
Self Tolerance
Skin / pathology
Suppressor of Cytokine Signaling Proteins
Thymus Gland / pathology
Transplantation, Isogeneic*
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/Cytokines; 0/Repressor Proteins; 0/Socs1 protein, mouse; 0/Suppressor of Cytokine Signaling Proteins; 82115-62-6/Interferon-gamma

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