Document Detail


The lethal effects of transplantation of Socs1-/- bone marrow cells into irradiated adult syngeneic recipients.
MedLine Citation:
PMID:  12821775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Injection of neonatal bone marrow cells from mice lacking the gene encoding suppressor of cytokine signaling 1 (SOCS1) into irradiated syngeneic 129/Sv or C57BL/6 mice led to a decreased survival, more rapidly occurring in 129/Sv than in C57BL/6 mice. Moribund mice did not exhibit the acute or chronic diseases developed by Socs1-/- mice but developed a pathology characteristic of graft-versus-host disease with typical chronic inflammatory lesions in the liver, skin, lungs, and gut. The results indicate that cells derived from the Socs1-/- bone marrow are autoaggressive but did not identify the cell types involved. Failure of the engrafted Socs1-/- marrow cells to reproduce the tissue damage typical of Socs1-/- disease indicates that loss of SOCS1 from target tissues may also be required for the development of the Socs1-/- diseases, such as fatty degeneration of the liver, polymyositis, or corneal inflammation.
Authors:
Donald Metcalf; Sandra Mifsud; Ladina Di Rago; Warren S Alexander
Related Documents :
15496135 - Inverse relationship between increased apoptosis and decreased skin cancer in uv-irradi...
7607925 - Acemannan-containing wound dressing gel reduces radiation-induced skin reactions in c3h...
16756565 - Anti-mouse cd154 antibody treatment facilitates generation of mixed xenogeneic rat hema...
11099165 - Recovery from sarafotoxin-b induced cardiopathological effects in mice following low en...
16728705 - Association of tnf haplotypes with asthma, serum ige levels, and correlation with serum...
9786435 - Experimental autoimmune myasthenia gravis induction in b cell-deficient mice.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-06-23
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  100     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2003-09-04     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8436-41     Citation Subset:  IM    
Affiliation:
Division of Cancer and Hematology, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia. metcalf@wehi.edu.au
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Transplantation*
Carrier Proteins / genetics,  physiology*
Cytokines / physiology
Genes, Lethal
Graft vs Host Disease
Interferon-gamma / physiology
Intestines / pathology
Kidney / pathology
Liver / pathology
Lung / pathology
Lymphoid Tissue / pathology
Mice
Mice, Inbred C57BL
Mice, Knockout
Myocardium / pathology
Radiation Chimera
Repressor Proteins*
Self Tolerance
Skin / pathology
Suppressor of Cytokine Signaling Proteins
Thymus Gland / pathology
Transplantation, Isogeneic*
Grant Support
ID/Acronym/Agency:
CA22556/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Cytokines; 0/Repressor Proteins; 0/Socs1 protein, mouse; 0/Suppressor of Cytokine Signaling Proteins; 82115-62-6/Interferon-gamma
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Sahara as a vicariant agent, and the role of Miocene climatic events, in the diversification of ...
Next Document:  Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices.