| The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis. | |
| | |
MedLine Citation:
|
PMID: 9973366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation. |
| | |
Authors:
|
Y Ohashi; Y Chijiiwa; K Suzuki; K Takahashi; H Nanamiya; T Sato; Y Hosoya; K Ochi; F Kawamura |
Related Documents
:
|
14255666 - Time-lapse photomicrography of cell growth and division in escherichia coli. 16421926 - A critical role for the type v myosin, myo52, in septum deposition and cell fission dur... 2802186 - Quantitative studies of mitotic cells in the chick embryo optic stalk during the early ... 9622526 - Selective synchronization of tetrahymena pyriformis cell populations and cell growth ki... 19402386 - Validation of cytopathology as a technique for analysis of epithelial cell maturation i... 1474926 - Intravital videomicroscopy of the chorioallantoic microcirculation: a model system for ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of bacteriology Volume: 181 ISSN: 0021-9193 ISO Abbreviation: J. Bacteriol. Publication Date: 1999 Feb |
Date Detail:
|
Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2013-04-17 |
Medline Journal Info:
|
Nlm Unique ID: 2985120R Medline TA: J Bacteriol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1348-51 Citation Subset: IM |
Affiliation:
|
Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo 171-8501, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Bacillus subtilis
/
cytology,
drug effects,
genetics* Bacterial Proteins / biosynthesis, genetics* Benzamides / toxicity* Cell Division / drug effects Cytoskeletal Proteins* Drug Resistance, Microbial / genetics Mutation* Poly(ADP-ribose) Polymerases / antagonists & inhibitors Sigma Factor* Spores, Bacterial / drug effects Suppression, Genetic* Transcription Factors* |
| Chemical | |
Reg. No./Substance:
|
0/Bacterial Proteins; 0/Benzamides; 0/Cytoskeletal Proteins; 0/FtsZ protein, Bacteria; 0/Sigma Factor; 0/Transcription Factors; 0/spoIIR protein, Bacillus subtilis; 0/spore-specific proteins, Bacillus; 5813-86-5/3-methoxybenzamide; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cloning and characterization of arylamine N-acetyltransferase genes from Mycobacterium smegmatis and...
Next Document: Bacteriophage T4 gp2 interferes with cell viability and with bacteriophage lambda Red recombination.