Document Detail

The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.
MedLine Citation:
PMID:  9973366     Owner:  NLM     Status:  MEDLINE    
3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell division system involving FtsZ function during both vegetative growth and sporulation.
Y Ohashi; Y Chijiiwa; K Suzuki; K Takahashi; H Nanamiya; T Sato; Y Hosoya; K Ochi; F Kawamura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bacteriology     Volume:  181     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-03-22     Completed Date:  1999-03-22     Revised Date:  2013-04-17    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1348-51     Citation Subset:  IM    
Laboratory of Molecular Genetics, College of Science, Rikkyo (St. Paul's) University, Toshima-ku, Tokyo 171-8501, Japan.
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MeSH Terms
Bacillus subtilis / cytology,  drug effects,  genetics*
Bacterial Proteins / biosynthesis,  genetics*
Benzamides / toxicity*
Cell Division / drug effects
Cytoskeletal Proteins*
Drug Resistance, Microbial / genetics
Poly(ADP-ribose) Polymerases / antagonists & inhibitors
Sigma Factor*
Spores, Bacterial / drug effects
Suppression, Genetic*
Transcription Factors*
Reg. No./Substance:
0/Bacterial Proteins; 0/Benzamides; 0/Cytoskeletal Proteins; 0/FtsZ protein, Bacteria; 0/Sigma Factor; 0/Transcription Factors; 0/spoIIR protein, Bacillus subtilis; 0/spore-specific proteins, Bacillus; 5813-86-5/3-methoxybenzamide; EC Polymerases

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