| The let-7 microRNA reduces tumor growth in mouse models of lung cancer. | |
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MedLine Citation:
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PMID: 18344688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MicroRNAs have been increasingly implicated in human cancer and interest has grown about the potential to use microRNAs to combat cancer. Lung cancer is the most prevalent form of cancer worldwide and lacks effective therapies. Here we have used both in vitro and in vivo approaches to show that the let-7 microRNA directly represses cancer growth in the lung. We find that let-7 inhibits the growth of multiple human lung cancer cell lines in culture, as well as the growth of lung cancer cell xenografts in immunodeficient mice. Using an established orthotopic mouse lung cancer model, we show that intranasal let-7 administration reduces tumor formation in vivo in the lungs of animals expressing a G12D activating mutation for the K-ras oncogene. These findings provide direct evidence that let-7 acts as a tumor suppressor gene in the lung and indicate that this miRNA may be useful as a novel therapeutic agent in lung cancer. |
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Authors:
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Aurora Esquela-Kerscher; Phong Trang; Jason F Wiggins; Lubna Patrawala; Angie Cheng; Lance Ford; Joanne B Weidhaas; David Brown; Andreas G Bader; Frank J Slack |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-03-03 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 7 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-04-21 Completed Date: 2008-09-15 Revised Date: 2008-12-05 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 759-64 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenoviridae Administration, Intranasal Animals Cell Line, Tumor Cell Proliferation Gene Therapy / methods* Genes, Tumor Suppressor* Genetic Vectors Humans Lung Neoplasms / genetics, therapy* Mice MicroRNAs / administration & dosage, therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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F32CA130376/CA/NCI NIH HHS; F32GM071157/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs; 0/mirnlet7 microRNA, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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