| let-7 and miR-17-92: small-sized major players in lung cancer development. | |
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MedLine Citation:
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PMID: 20735434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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MicroRNA (miRNA)-encoding small non-coding RNA have been recognized as important regulators of a number of biological processes that inhibit the expression of hundreds of genes. Accumulating evidence also indicates the involvement of miRNA alterations in various types of human cancer, including lung cancer, which has long been the leading cause of cancer death in economically well-developed countries, including Japan. We previously found that downregulation of members of the tumor-suppressive let-7 miRNA family and overexpression of the oncogenic miR-17-92 miRNA cluster frequently occur in lung cancers, and molecular insight into how these miRNA alterations may contribute to tumor development has been rapidly accumulating. The present review summarizes recent advances in elucidation of the molecular functions of these miRNA in relation to their roles in the pathogenesis of lung cancer. Given the crucial roles of miRNA alterations, additional studies are expected to provide a better understanding of the underlying molecular mechanisms of disease development, as well as a foundation for novel strategies for cancer diagnosis and treatment of this devastating disease. |
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Authors:
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Hirotaka Osada; Takashi Takahashi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cancer science Volume: 102 ISSN: 1349-7006 ISO Abbreviation: Cancer Sci. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-16 Completed Date: 2011-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168776 Medline TA: Cancer Sci Country: England |
Other Details:
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Languages: eng Pagination: 9-17 Citation Subset: IM |
Copyright Information:
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© 2010 Japanese Cancer Association. |
Affiliation:
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Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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E2F1 Transcription Factor
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physiology Genes, myc Humans Lung Neoplasms / etiology*, genetics MicroRNAs / analysis, physiology* |
| Chemical | |
Reg. No./Substance:
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0/E2F1 Transcription Factor; 0/E2F1 protein, human; 0/MIRN17 microRNA, human; 0/MicroRNAs; 0/mirnlet7 microRNA, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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