Document Detail


The lesser known story of X chromosome reactivation: a closer look into the reprogramming of the inactive X chromosome.
MedLine Citation:
PMID:  22234239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
X-chromosome inactivation (XCI) is an important mechanism employed by mammalian XX female cells to level X-linked gene expression with that of male XY cells. XCI occurs early in development as the pluripotent cells of the inner cell mass (ICM) in blastocysts successively differentiate into cells of all three germ layers. X-chromosome reactivation (XCR), the reversal of XCI, is critical for germ cell formation as a mechanism to diversify the X-chromosome gene pool. Here we review the characterization of XCR, and further explore its natural occurrence during development and the in vitro models of cellular reprogramming. We also review the key regulators involved in XCI for their role in suppressing the active histone marks and the genes in the active chromosome for their inhibition of X inactivation signals.
Authors:
Eriona Hysolli; Yong Wook Jung; Yoshiaki Tanaka; Kun-Yong Kim; In-Hyun Park
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-01-15
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  11     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-06     Completed Date:  2012-08-30     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  229-35     Citation Subset:  IM    
Affiliation:
Department of Genetics, Yale Stem Cell Center, Yale School of Medicine, New Haven, CT, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line, Tumor
DNA Methylation
Gene Expression Regulation, Developmental
Histones / metabolism
Humans
Pluripotent Stem Cells / metabolism
RNA Interference
Ubiquitin-Protein Ligases / metabolism
X Chromosome / genetics,  metabolism*
X Chromosome Inactivation*
Grant Support
ID/Acronym/Agency:
GM099130-01/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Histones; EC 6.3.2.-/RLIM protein, human; EC 6.3.2.19/Ubiquitin-Protein Ligases
Comments/Corrections

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