| The lens circulation. | |
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MedLine Citation:
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PMID: 17568975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lens is the largest organ in the body that lacks a vasculature. The reason is simple: blood vessels scatter and absorb light while the physiological role of the lens is to be transparent so it can assist the cornea in focusing light on the retina. We hypothesize this lack of blood supply has led the lens to evolve an internal circulation of ions that is coupled to fluid movement, thus creating an internal micro-circulatory system, which makes up for the lack of vasculature. This review covers the membrane transport systems that are believed to generate and direct this internal circulatory system. |
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Authors:
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Richard T Mathias; Joerg Kistler; Paul Donaldson |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2007-06-14 |
Journal Detail:
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Title: The Journal of membrane biology Volume: 216 ISSN: 0022-2631 ISO Abbreviation: J. Membr. Biol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-09-10 Completed Date: 2007-10-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0211301 Medline TA: J Membr Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1-16 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, NY 11794-8661, USA. richard.mathias@sunysb.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Aquaporins / physiology Biological Transport / physiology* Cataract / physiopathology Cell Size Chlorides / metabolism Gap Junctions / physiology Humans Lens, Crystalline / blood supply, cytology, physiology* Sodium / metabolism Sodium-Potassium-Exchanging ATPase / physiology |
| Grant Support | |
ID/Acronym/Agency:
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EY06391/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Aquaporins; 0/Chlorides; 7440-23-5/Sodium; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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