| The leishmanicidal effect of (3S)-16,17-didehydrofalcarinol, an oxylipin isolated from Tridax procumbens, is independent of NO production. | |
| | |
MedLine Citation:
|
PMID: 19953523 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The in vitro leishmanicidal effect of (3S)-16,17-didehydrofalcarinol (1) isolated from Tridax procumbens whole plant against Leishmania mexicana, the causative agent of cutaneous leishmaniasis (chiclero's ulcer) in the New World, was investigated. This oxylipin showed significant in vitro activity against promastigotes and intracellular amastigotes of L. mexicana. Its inhibitory effect on amastigotes was not due to activation of NO in recombinant gamma-interferon-stimulated macrophages, since the production of NO was decreased in presence of the oxylipin. This is the first report on the leishmanicidal activity against the intracellular stage (amastigote) of the oxylipin (3S)-16,17-didehydrofalcarinol. |
| | |
Authors:
|
Zhelmy Martín-Quintal; María del Rosario García-Miss; Mirza Mut-Martín; Abril Matus-Moo; Luis W Torres-Tapia; Sergio R Peraza-Sánchez |
Related Documents
:
|
1516623 - Mechanisms of resistance to leishmania aethiopica. i. interferon-gamma in combination w... 3127233 - Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infe... 21371163 - Cellular sources and inducers of cytokines present in acute wound fluid. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Phytotherapy research : PTR Volume: 24 ISSN: 1099-1573 ISO Abbreviation: Phytother Res Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-30 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8904486 Medline TA: Phytother Res Country: England |
Other Details:
|
Languages: eng Pagination: 1004-8 Citation Subset: IM |
Affiliation:
|
Centro de Investigación Científica de Yucatán, Calle 43 #130, Col. Chuburná de Hidalgo, Mérida, Yucatán, México. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antiprotozoal Agents / pharmacology* Asteraceae / chemistry Fatty Alcohols / pharmacology* Interferon-gamma, Recombinant / pharmacology Leishmania mexicana / drug effects* Leishmaniasis, Cutaneous / drug therapy* Macrophages / drug effects Male Mice Mice, Inbred BALB C Nitric Oxide / metabolism Oxylipins / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Antiprotozoal Agents; 0/Fatty Alcohols; 0/Interferon-gamma, Recombinant; 0/Oxylipins; 10102-43-9/Nitric Oxide; 110927-49-6/didehydrofalcarinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Degradation and Adsorption Behaviors of Enzyme on Poly(butylene succinate) Single Crystals.
Next Document: Effect of Buguzhi (Psoralea corylifolia fruit) extract on bone formation.