Document Detail

For left ventricular opacification and endocardial border definition: is it really important which contrast agent we use, or is it the imaging modality we choose?
MedLine Citation:
PMID:  11882448     Owner:  NLM     Status:  MEDLINE    
AIMS: The purpose of this study was to prospectively compare the effect of three imaging modalities (fundamental, harmonics, and power harmonics) on left ventricular opacification and endocardial border definition with two different echo agents, Optison and Albunex. METHODS: A total of 84 patients who had suboptimal transthoracic images were studied with echo contrast agents Albunex (n=41) and Optison (n=43). Each contrast agent was examined with three different imaging modalities, fundamental, harmonics and power harmonics, respectively. Left ventricular opacification was obtained by videodensitometric analysis. Percentage of endocardial border visualization was determined by indexing circumference of visualized endocardium to total circumference. Variables were compared with respect to three imaging modalities between two different echo agents. RESULTS: Higher videointensities and higher percentages of endocardial visualization were achieved with Optison compared to Albunex with fundamental and harmonics. However, there was no significant difference between Optison and Albunex with respect to LV opacification and border visualization by power harmonics. CONCLUSION: These results indicate that left ventricular opacification and endocardial border visualization is significantly improved by using power harmonic imaging as compared to harmonics or fundamental imaging following both echo contrast agents. Furthermore, although Optison is clearly superior to Albunex in opacifying left ventricle, power harmonic imaging compensates for the less robust agent.
M S Dolan; A El-Shafei; S Puri; K Tamirisa; J St Vrain; J Flanagan; E Havens; A J Labovitz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology     Volume:  2     ISSN:  1525-2167     ISO Abbreviation:  Eur J Echocardiogr     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2002-03-07     Completed Date:  2002-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100890618     Medline TA:  Eur J Echocardiogr     Country:  England    
Other Details:
Languages:  eng     Pagination:  154-62     Citation Subset:  IM    
Saint Louis University Health Sciences Center, Saint Louis, Missouri, USA.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Chi-Square Distribution
Contrast Media*
Echocardiography / methods*,  standards*
Endocardium / ultrasonography*
Heart Ventricles / ultrasonography
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Contrast Media
Comment In:
Eur J Echocardiogr. 2001 Sep;2(3):143-4   [PMID:  11882444 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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