Document Detail


Is left ventricular hypertrophy a risk factor in hypertensive patients?
MedLine Citation:
PMID:  12448569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Left ventricular hypertrophy (LVH) is supposed to be a risk factor of cardiovascular (CV) complications in hypertensive patients. AIM: To compare clinical events in hypertensives with and without LVH. PATIENTS AND METHODS: 319 hypertensives with LVH (mean age 64.1+/-10.6 ys) and 177 hypertensives without LVH (mean age 62.5+/-11.3 ys). LVH defined by echo Penn convention as left ventricular mass index >134 g/m2 in men and >110 g/m2 in women. Clinical events--heart failure (EF<40 %), left ventricular diastolic dysfunction (echo-doppler: transmitral-flow where peak A>peak E), myocardial infarction (history, ECG, cardiac enzymes), chronic atrial fibrillation (more than 2 weeks duration), mitral regurgitation (echo) and renal involvement (creatininemia>120 micromol/l). The two groups of hypertensives were matched by demographic criteria, duration and intensity of hypertension, obesity, diabetes mellitus, lipid serum levels and smoking habits. RESULTS: There were statistically significant at least p<0.05 more CV events (heart failure, left ventricular diastolic dysfunction, myocardial infarction, chronic atrial fibrillation, and mitral regurgitation cases) and renal involvement in LVH-positive patients than in LVH-negative patients. CONCLUSION: LVH is a strong risk factor for clinical events in hypertensives, which necessitates their more intensive treatment, mainly with drugs producing also LVH regression. (Tab. 5, Ref. 48.)
Authors:
Wisam M A Ghanem; J Murin; O Sleiman; J Bulas; J Jaber; P Mikes; L Baqi; A Radman; K Kozlikova; A Reptova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bratislavské lekárske listy     Volume:  103     ISSN:  0006-9248     ISO Abbreviation:  Bratisl Lek Listy     Publication Date:  2002  
Date Detail:
Created Date:  2002-11-22     Completed Date:  2002-12-12     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0065324     Medline TA:  Bratisl Lek Listy     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Affiliation:
1st Internal Department, University Hospital, Comenius University, Bratislava, Slovakia.
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Hypertension / complications*,  drug therapy
Hypertrophy, Left Ventricular / diagnosis,  etiology*
Male
Middle Aged
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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