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The left-right difference in fetal liver oxygenation during hypoxia, as estimated by BOLD MRI in a fetal sheep model.
MedLine Citation:
PMID:  21557372     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to measure the differences in oxygenation between the left and right side of the fetal liver during varying oxygenation levels. METHODS: Eight ewes carrying singleton fetuses at gestation 125 days (term 145 days) were included in the study. During anesthesia the ewes were ventilated with gas containing different levels of oxygen, thereby subjecting the fetuses to hyperoxia (mean maternal arterial pO2 = 23.2 ± 8.2 kPa (Mean ± SD)) as well as hypoxia (mean maternal arterial pO2 = 7.1 ± 0.5 kPa Mean ± SD)). Changes in oxygenation within the fetal liver were assessed by BOLD (Blood-Oxygen-Level-Dependent) MRI (Magnetic Resonance Imaging). RESULTS: During hyperoxia, there was no difference between the BOLD signal in the left and the right side of the fetal liver, ΔBOLDHyperoxia = -0.9 ± 3.7% (Mean ± SD). During hypoxia, however, the decrease in the BOLD signal was more pronounced in the right side as compared to the left side, thereby creating a significant increase in the left-right difference in the BOLD signal, Δ BOLDHypoxia= 5.2 ± 2.2% (Mean ± SD), (p.0.002, paired t-test). The left-right difference was directly proportional to the degree of hypoxia (R 2 = 0.85, p =0.007). CONCLUSIONS: To our knowledge, this is the first study demonstrating differences in oxygenation between the left and right side of the fetal liver during hypoxia. This left-right difference can be explained by increased ductus venosus shunting. Thus, the BOLD MRI technique is a promising non-invasive tool, which might be useful for the future monitoring of human fetuses. Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Authors:
Anne Sørensen; David Holm; Michael Pedersen; Anna Tietze; Brian Stausbøl-Grøn; Liv Duus; Niels Uldbjerg
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-6
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 ISUOG. Published by John Wiley & Sons, Ltd.
Affiliation:
Aarhus University Hospital, Aalborg, Department of Gynecology and Obstetrics. ans@rn.dk.
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