Document Detail

Is the left atrial appendage more than a simple appendage?
MedLine Citation:
PMID:  19360867     Owner:  NLM     Status:  MEDLINE    
The left atrial appendage (LAA) is a cardiac structure with unique anatomic and functional features. It is significantly more than a simple chamber appended to the left atrium (LA), differing from the LA in structure, function, and hormonal activity. Unfortunately, it is the source of more than 90% of cardiac-based emboli, particularly in atrial fibrillation, mandating lifelong anticoagulation. Percutaneous LAA exclusion was developed to limit or eliminate cardioembolic events in patients with atrial fibrillation. Benign healing of the appendage occurs without adverse hemodynamic effects, and with no residual surface thrombus or tissue damage. The feasibility of this treatment is now established, suggesting that percutaneous therapy is safe, practical and possibly effective to eliminate the need for anticoagulation and significantly reduce cardioembolic events.
Hidehiko Hara; Renu Virmani; David R Holmes; Maurice Buchbinder; John R Lesser; Robert A Van Tassel; Michael R Mooney; Robert S Schwartz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  74     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-42     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley-Liss, Inc.
Minneapolis Heart Institute and Foundation, Minneapolis, Minnesota, USA.
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MeSH Terms
Aged, 80 and over
Anticoagulants / adverse effects,  therapeutic use*
Atrial Appendage / pathology,  physiopathology,  surgery*
Atrial Fibrillation / complications,  pathology,  physiopathology,  therapy*
Cardiac Surgical Procedures* / adverse effects
Embolism / etiology,  prevention & control*
Heart Catheterization / adverse effects,  methods*
Middle Aged
Risk Assessment
Risk Factors
Treatment Outcome
Wound Healing
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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