Document Detail


The leading role of membrane Ca(2+)-ATPase in recovery of Ca(2+) homeostasis after glutamate shock.
MedLine Citation:
PMID:  12802418     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Combined blockade of Na(+)/Ca(2+) exchange, Ca(2+) uptake by mitochondria and endoplasmic reticulum usually does not prevent recovery of the basal level of intracellular Ca(2+) after 1-min action of glutamate (100 microM) or K(+) (50 mM). However, replacement of Ca(2+) with Ba(2+), which cannot be transported by Ca(2+)-ATPase, considerably delayed the decrease in intracellular Ba(2+) after its rise caused by glutamate or potassium application in all examined cells, which attest to an important role of Ca(2+)-ATPase in Ca(2+) extrusion after the action of glutamate or K(+).
Authors:
T P Storozhevykh; V G Pinelis; N P Vinskaya; A M Surin; B I Khodorov
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  135     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-06-12     Completed Date:  2004-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-42     Citation Subset:  IM    
Affiliation:
Laboratory of Membranology, Research Center of Children Health, Russian Academy of Medical Sciences, Moscow. tstor@mail.ru
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Barium / metabolism
Calcium / metabolism*
Calcium-Transporting ATPases / metabolism*
Cells, Cultured
Cerebellum / cytology
Excitatory Amino Acid Antagonists / metabolism
Glutamic Acid / metabolism*
Homeostasis*
Lithium / metabolism
Neurons / cytology,  metabolism
Potassium / metabolism
Quinoxalines / metabolism
Rats
Rats, Wistar
Spectrometry, Fluorescence
Chemical
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/Quinoxalines; 118876-58-7/2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline; 56-86-0/Glutamic Acid; 7439-93-2/Lithium; 7440-09-7/Potassium; 7440-39-3/Barium; 7440-70-2/Calcium; EC 3.6.1.8/Calcium-Transporting ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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