| Is the lattice dystrophy of the cornea due to developmental anomalies of neural crest cells during embryogenesis (neurocristopathies)? | |
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MedLine Citation:
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PMID: 18333410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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With the present paper authors try to give an embryological approach in understanding etiopathogenesis of lattice corneal dystrophy (LCD). The case of a 41-years-old man affected by isolated LCD has been examined at the Ophtalmologic Clinic of the University of Catania, Italy. Sore cornea has been excised during cornea transplantation, and it has been examined by transmission electron microscopy (TEM). Results confirm classic submicroscopic findings described in literature. However these findings offer possibility to consider an embryological interpretation of LCD pathogenesis. Our findings with those of literature put forward hypothesis of a hereditary etiopathogenetical role exerted by keratocytes, direct derivatives of neural crest cells during embryogenesis, probably via an abnormal gene expression in producing proteinaceous precursor of amyloid substance (APP). LCD could be considered a neurocristopathy. |
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Authors:
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Paola Castrogiovanni; Rosa Imbesi; Fabio D'Amico; Vera Mazzone; Nicolò Cavallaro |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia Volume: 112 ISSN: 1122-6714 ISO Abbreviation: Ital J Anat Embryol Publication Date: 2007 Oct-Dec |
Date Detail:
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Created Date: 2008-03-12 Completed Date: 2008-04-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612303 Medline TA: Ital J Anat Embryol Country: Italy |
Other Details:
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Languages: eng Pagination: 255-66 Citation Subset: IM |
Affiliation:
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Department of Biomedical Science, University of Catania, Italy. pacastro@unict.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amyloid beta-Protein / biosynthesis Amyloid beta-Protein Precursor / genetics, metabolism Cornea / abnormalities*, pathology*, physiopathology Corneal Dystrophies, Hereditary / genetics, pathology*, physiopathology Descemet Membrane / metabolism, pathology Embryonic Development / physiology Endothelium, Corneal / metabolism, pathology Genetic Predisposition to Disease / genetics Humans Keratinocytes / metabolism, pathology Male Microscopy, Electron, Transmission Neural Crest / cytology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein; 0/Amyloid beta-Protein Precursor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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