Document Detail


The latest on infantile spasms.
MedLine Citation:
PMID:  15791136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This article reviews the most significant advances in the field of infantile spasm during the past year, with emphasis on best practise for treatment, and on some new etiological genetic and metabolic causes for the spasms, and new advances in the knowledge of tuberous sclerosis.
RECENT FINDINGS: Up-to-date information comparing corticotrophin, oral steroids and vigabatrin shows that hormonal treatment is the most effective therapy in the short term. In a recent randomized trial, large doses of prednisolone were as effective as corticotrophin. There are insufficient data to recommend any treatment schedule for infantile spasms. Vigabatrin is the choice for infants with tuberous sclerosis. Visual field defects in (older) children seem to be as common as in adults. In animals, vigabatrin can induce apoptosis of the neurons in the developing brain. New rare factors associated with infantile spasms are mitochondrial diseases, mutations of the Aristales-related homeobax gene and posterior quadrantic dysplasia syndrome. The outcome in children with tuberous sclerosis and infantile spasms is better understood.
SUMMARY: The accurate determination of etiology is now becoming increasingly possible. There is still a lack of consensus about the treatment of first choice for infantile spasms. However, recent data show that hormonal treatment is the most effective therapy in the short term. Frequency of visual field defects in children treated with vigabatrin should be studied in addition to the long-term outcome in general. Advances in our understanding of brain maturation, etiologies, mechanisms and genetics underlying catastrophic epilepsy may facilitate more effective pharmacologic interventions.
Authors:
Raili Riikonen
Related Documents :
12060016 - Clinical and genetic analysis of a new multigenerational pedigree with gefs+ (generaliz...
8174286 - P300 event-related potentials in epileptic children.
7211376 - Follow-up study of phototreated fullterm newborns.
18759616 - Expanding the role of surgery in intractable extratemporal pediatric epilepsy.
23937056 - A systematic review of activities of daily living measures for children and adolescents...
23460036 - Sensitisation patterns and association with age, gender, and clinical symptoms in child...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  18     ISSN:  1350-7540     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-25     Completed Date:  2005-06-13     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  91-5     Citation Subset:  IM    
Affiliation:
Children's Hospital, University of Kuopio, Finland. raili.riikonen@uku.fi
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anticonvulsants / therapeutic use*
Humans
Infant
Spasms, Infantile / drug therapy*,  etiology*
Steroids / therapeutic use*
Vigabatrin / therapeutic use*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Steroids; 60643-86-9/Vigabatrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The Apgar score has survived the test of time.
Next Document:  Rett syndrome.