Document Detail

The latest generation of beta-blockers: new pharmacologic properties.
MedLine Citation:
PMID:  16884657     Owner:  NLM     Status:  MEDLINE    
beta-Blockers have generally demonstrated smaller reductions in cardiovascular events, compared with other antihypertensive classes, despite similar reductions in blood pressure. This may be due to the ineffectiveness of traditional beta-blockers, such as atenolol, in reducing central aortic pressure, a strong, independent predictor of cardiovascular outcome. However, the beta-blocker class is heterogeneous, and some newer beta-blockers, which exhibit vasodilatory effects independent of beta-blockade, provide beneficial effects on arterial stiffness and endothelial dysfunction, which may lead to reductions in central aortic pressure and improvements in clinical outcomes. For example, the vasodilating beta-blocker nebivolol was shown to improve forearm blood flow and arterial stiffness and, in a large clinical study, to significantly reduce morbidity and mortality, independent of left ventricular ejection fraction, among patients with chronic heart failure. Further research is warranted to investigate any potential differences between traditional and newer vasodilating beta-blockers on cardiovascular outcomes.
Michala E Pedersen; John R Cockcroft
Related Documents :
6178707 - Influence of the adrenergic nervous system on the lower urinary tract and its clinical ...
22854637 - Blood pressure control in italian essential hypertensives treated by general practition...
6142877 - Function of canine diaphragm with hypovolemic shock and beta-adrenergic blockade.
8102527 - Effects of propranolol, pindolol and carteolol on acute regional myocardial ischemia in...
17252227 - Prolonged lateral steep position impairs respiratory mechanics during continuous latera...
15204757 - Effects of concentrated ambient particles on heart rate, blood pressure, and cardiac co...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  8     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-03     Completed Date:  2006-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  279-86     Citation Subset:  IM    
Department of Cardiology, Wales Heart Research Institute, Cardiff University, Heath Park, Cardiff CF14 4XN, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenergic beta-Antagonists / pharmacology*,  therapeutic use
Blood Pressure / drug effects
Cardiovascular Diseases / drug therapy,  physiopathology
Coronary Circulation / drug effects
Endothelium, Vascular / drug effects,  physiopathology
Forearm / blood supply
Regional Blood Flow / drug effects
Stroke Volume / drug effects
Vasodilator Agents / pharmacology
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Vasodilator Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A self-destruction game.
Next Document:  Monitoring vascular health beyond blood pressure.