Document Detail

The late effects of selected immunosuppressants on immunocompetence, disease incidence, and mean life-span. I. Humoral immune activity.
MedLine Citation:
PMID:  1081633     Owner:  NLM     Status:  MEDLINE    
The effect of different immunosuppressive treatments during young adulthood or humoral immune competence late in life was determined. It was found that the marked reduction in humoral immune competence in aged mice is further compromised when severe insults are administered early in life. Thus, thymectomy, splenectomy, and sublethal X-irradiation produced lasting immunodepression as measured (1) in situ and (2) by the hemolysin, direct and indirect plaque forming cell responses of adoptively transferred spleen cells. In contrast, treatment with cyclophosphamide and cortisone acetate were without effect, indicating that drug-damaged cells of the immune system were replaced by competent cells during the course of time. Decrease in immune competence of aged thymectomized animals could not be correlated with a decrease in numbers of theta-bearing T or immunoglobulin receptor-bearing B lymphocytes. The significance of the observed unequal effects of these immunosuppressants on immune competence, as they relate to disease incidence and life expectancy, are dealt with in the third paper in this series.
E H Perkins; W J Peterson; C F Gottlieb; M K Halsall; L H Cacheiro; T Makinodan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Mechanisms of ageing and development     Volume:  4     ISSN:  0047-6374     ISO Abbreviation:  Mech. Ageing Dev.     Publication Date:    1975 May-Aug
Date Detail:
Created Date:  1976-02-13     Completed Date:  1976-02-13     Revised Date:  2007-11-06    
Medline Journal Info:
Nlm Unique ID:  0347227     Medline TA:  Mech Ageing Dev     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  231-9     Citation Subset:  IM    
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MeSH Terms
Age Factors
Antibody Formation / drug effects*,  radiation effects
B-Lymphocytes / immunology
Cortisone / pharmacology*
Cyclophosphamide / pharmacology*
Hemolysin Proteins / analysis
Immunity, Cellular / drug effects,  radiation effects
Longevity / drug effects*,  radiation effects
Mice, Inbred Strains
Radiation Injuries, Experimental / immunology
T-Lymphocytes / immunology
Reg. No./Substance:
0/Hemolysin Proteins; 50-18-0/Cyclophosphamide; 53-06-5/Cortisone

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