| A laser microprobe mass analysis of brain aluminum and iron in dementia pugilistica: comparison with Alzheimer's disease. | |
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MedLine Citation:
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PMID: 9252800 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report a laser microprobe mass analysis of aluminum and iron content in the hippocampus and in the inferior temporal cortex in 2 cases of dementia pugilistica (DP), 4 cases of Alzheimer's disease (AD), and 3 controls. There was a predominant accumulation of Al and Fe within neurofibrillary tangles (NFT) in both DP and AD cases. High levels of Al and Fe were also detected in the nuclei of NFT-free and NFT-containing neurons, as well as in neuropil probe sites in these cases. In both regions, NFT contained substantially higher levels of Al and Fe in DP compared to AD cases. These findings suggest the existence of an association between the deposition of Al and Fe and NFT formation, and support the possibility of a global dysregulation of Al and Fe transport in DP and AD. |
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Authors:
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C Bouras; P Giannakopoulos; P F Good; A Hsu; P R Hof; D P Perl |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European neurology Volume: 38 ISSN: 0014-3022 ISO Abbreviation: Eur. Neurol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-10-15 Completed Date: 1997-10-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, HUG Belle-Idée, University of Geneva School of Medicine, Switzerland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aluminum / analysis* Alzheimer Disease / pathology*, physiopathology Boxing / injuries* Brain / pathology* Brain Chemistry* Case-Control Studies Dementia / etiology, pathology*, physiopathology Hippocampus / chemistry, pathology Humans Iron / analysis* Lasers / diagnostic use* Middle Aged Nerve Fibers / chemistry, pathology Neurofibrillary Tangles / chemistry, pathology Neurons / chemistry, pathology Occupational Diseases / pathology*, physiopathology Temporal Lobe / chemistry, pathology |
| Grant Support | |
ID/Acronym/Agency:
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AG05138/AG/NIA NIH HHS; AG08802/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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7429-90-5/Aluminum; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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