| A laser Doppler instrument for in vivo measurements of blood flow in single renal arterioles. | |
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MedLine Citation:
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PMID: 8335333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A laser Doppler instrument has been developed to measure the blood flow in single vessels for the study of the dynamics of local control mechanisms. A commercial blood perfusion monitor, designed to measure blood perfusion in a vascular field containing many randomly oriented blood vessels, was modified to perform measurements of blood flow in a single arteriole. In vitro tests of the instrument revealed that the relationship between blood flow and Doppler shift was not a simple linear function. Causes of nonlinearity are revealed and proper use of the device avoids the problem. The device was applied to efferent arterioles that are visible on the surface of the rat kidney. An angiotensin converting enzyme inhibitor and graded doses of angiotensin II were used to perturb kidney blood flow. The induced changes in whole kidney blood flow, measured with an electromagnetic flow probe, and in single efferent arteriolar blood flow, measured with the new instrument, were correlated. An oscillation at approximately 0.035 Hz, previously described in the tubular pressure and attributed to a local feedback mechanism acting on arteriolar resistance, was found in the arteriolar blood flow. The new instrument is easy to use and provides temporal resolution not available with more conventional methods used for flow measurement in the microcirculation. |
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Authors:
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G Smedley; K P Yip; A Wagner; S Dubovitsky; D J Marsh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: IEEE transactions on bio-medical engineering Volume: 40 ISSN: 0018-9294 ISO Abbreviation: IEEE Trans Biomed Eng Publication Date: 1993 Mar |
Date Detail:
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Created Date: 1993-08-26 Completed Date: 1993-08-26 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0012737 Medline TA: IEEE Trans Biomed Eng Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 290-7 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, School of Medicine, University of Southern California, Los Angeles 90033. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterioles / ultrasonography Equipment Design Laser-Doppler Flowmetry / instrumentation* Male Models, Cardiovascular* Rats Rats, Sprague-Dawley Renal Circulation / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DK 15968/DK/NIDDK NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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