Document Detail

A large high-density lipoprotein enriched in apolipoprotein C-I: a novel biochemical marker in infants of lower birth weight and younger gestational age.
MedLine Citation:
PMID:  15840864     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Low birth weight is associated with increased cardiovascular disease in adulthood, and differences in the molecular weight, composition, and quantity of lipoprotein subclasses are associated with coronary artery disease.
OBJECTIVE: To determine if there are novel patterns of lipoprotein heterogeneity in low-birth-weight infants.
DESIGN, SETTING, AND PARTICIPANTS: Prospective study at a US medical center of a representative sample of infants (n = 163; 70 white and 93 black) born at 28 or more weeks of gestational age between January 3, 2000, and September 27, 2000. This sample constituted 20% of all infants born during the study period at this site.
MAIN OUTCOME MEASURES: Plasma levels and particle sizes of lipoprotein subclasses and plasma concentrations of lipids, lipoproteins (high-density lipoprotein [HDL] and low-density lipoprotein [LDL]), and apolipoproteins.
RESULTS: An elevated lipoprotein peak of a particle with density between 1.062 and 1.072 g/mL was identified using physical-chemical methods. This subclass of large HDL was enriched in apolipoprotein C-I (apo C-I). Based on the amount of the apo C-I-enriched HDL peak, 156 infants were assigned to 1 of 4 groups: 0 (none detected), 17%; 1 (possibly present), 41%; 2 (probably present), 22%; 3 (elevated), 19%. Infants in group 3, compared with those in the other 3 groups, had significantly (P<.001) lower mean birth weight (2683.7 vs 3307.1 g) and younger mean gestational age (36.2 vs 39.3 wk). After correction for age, infants in group 3 had significantly higher levels of total and large HDL cholesterol and of total and large LDL cholesterol and LDL particle number. However, infants in group 3 had lower levels of small HDL, very low-density lipoproteins, and triglycerides than infants in the other 3 groups. This lipoprotein profile differed from that in infants born small for gestational age, who had significantly higher triglyceride (P<.001) and apo B (P = .04) levels, but lower levels of total and large HDL cholesterol (P<.001) and apo A-I (P<.001).
CONCLUSIONS: Because apo C-I-enriched HDL, and purified apo C-I alone, promotes apoptosis in vitro, increased amounts of this particle may have physiological significance and identify a novel group of low-birth-weight infants apparently distinct from traditionally classified small-for-gestational-age infants.
Peter O Kwiterovich; Steven L Cockrill; Donna G Virgil; Elizabeth S Garrett; James Otvos; Carolyn Knight-Gibson; Petar Alaupovic; Trudy Forte; Lin Zhang; Zachlyn N Farwig; Ronald D Macfarlane
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  293     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-20     Completed Date:  2005-04-22     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1891-9     Citation Subset:  AIM; IM    
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MeSH Terms
African Continental Ancestry Group
Apolipoprotein C-I
Apolipoproteins C / blood*
Biological Markers / blood
Cardiovascular Diseases
European Continental Ancestry Group
Fetal Blood
Gestational Age
Infant, Low Birth Weight / blood*
Infant, Newborn
Infant, Premature / blood
Infant, Small for Gestational Age / blood*
Linear Models
Lipids / blood
Lipoproteins, HDL / blood*
Particle Size
Prospective Studies
Grant Support
Reg. No./Substance:
0/Apolipoprotein C-I; 0/Apolipoproteins C; 0/Biological Markers; 0/Lipids; 0/Lipoproteins, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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