Document Detail

β-Lactoglobulin tablets as a suitable vehicle for protection and intestinal delivery of probiotic bacteria.
MedLine Citation:
PMID:  21129464     Owner:  NLM     Status:  In-Data-Review    
The use of succinylated β-lactoglobulin as a novel functional tablet excipient for the protection of probiotic bacteria against the adverse gastric conditions and their delivery in the intestine was studied. Tablets were produced by direct compression of a dry mixture of Bifidobacterium longum HA-135 and the tested excipient. The results showed that tablets made of native β-lg did not ensure cell survival while grafting carboxylic acid groups on the protein revealed to be an innovative method to create a gastroresistant matrix that could allow the survival of up to 10(8)CFU and 10(7)CFU after 1h and 2h gastric incubation, respectively. When compared to other polymers, succinylated β-lg promoted the best survival both upon compression and after simulated gastric passage. The proportion of succinylated β-lg in the formulation could be lowered to 60% without modifying the protective ability of the matrix. Additionally, the tablets proved to be stable over a period of 3 months when refrigerated. Succinylated β-lg tablets are an interesting vehicle for the protection of acid-sensitive bacteria during transit in the upper gastro-intestinal tract.
Jean-François Poulin; Romain Caillard; Muriel Subirade
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Publication Detail:
Type:  Journal Article     Date:  2010-12-01
Journal Detail:
Title:  International journal of pharmaceutics     Volume:  405     ISSN:  1873-3476     ISO Abbreviation:  Int J Pharm     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804127     Medline TA:  Int J Pharm     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Chaire de recherche du Canada sur les protéines, les biosystèmes et les aliments fonctionnels, Institut des nutraceutiques et des aliments fonctionnels (INAF), Département des sciences des aliments et de nutrition, Pavillon Paul Comtois, Université Laval, Québec, Canada G1K 7P4.
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