Document Detail

The lactic acid response to alkalosis in panic disorder : an integrative review.
MedLine Citation:
PMID:  11207326     Owner:  NLM     Status:  MEDLINE    
Panic patients consistently show exaggerated lactic acid response to alkalosis, whether produced by hyperventilation or by sodium lactate infusion. Understanding why this occurs may provide important clues to the pathogenesis of panic disorder. Although brain hypoxia from excessive hypocapnia-induced cerebral vasoconstriction is often cited as the mechanism of elevated brain lactic acid in panic disorder, studies of brain metabolism show that hypocapnia rarely leads to brain hypoxia. Increased lactic acid production is a normal response to intracellular alkalosis and to intracellular cyclic AMP. Thus, other possible mechanisms of the exaggerated lactic acid response in panic disorder include a disturbance of mechanisms regulating intracellular pH and factors increasing intracellular cyclic AMP. Both mechanisms are consistent with the suffocation false alarm theory of panic disorder. This review suggests a theoretical framework for future magnetic resonance spectroscopy studies that can test some of the predictions of these competing models.
R J Maddock
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of neuropsychiatry and clinical neurosciences     Volume:  13     ISSN:  0895-0172     ISO Abbreviation:  J Neuropsychiatry Clin Neurosci     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-06-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8911344     Medline TA:  J Neuropsychiatry Clin Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  22-34     Citation Subset:  IM; S    
Department of Psychiatry, University of California Davis School of Medicine, 95817, USA.
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MeSH Terms
Alkalosis / blood*
Arousal / physiology
Brain / physiopathology
Lactic Acid / blood*
Panic Disorder / blood*,  diagnosis
Reg. No./Substance:
50-21-5/Lactic Acid

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