Document Detail

The lack of transplacental movement of the cyanide antidote thiosulfate in gravid ewes.
MedLine Citation:
PMID:  10589625     Owner:  NLM     Status:  MEDLINE    
IMPLICATIONS: We evaluated the mechanism of action of sodium thiosulfide (STS) in sodium nitroprusside-induced cyanide toxicity in the ewe. Fetal cyanide poisoning is alleviated by maternal administration of STS, although this cyanide antidote apparently does not cross the placenta.
K A Graeme; S C Curry; D S Bikin; F A Lo Vecchio; T A Brandon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  89     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1999 Dec 
Date Detail:
Created Date:  1999-12-30     Completed Date:  1999-12-30     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1448-52     Citation Subset:  AIM; IM    
Department of Medical Toxicology, Good Samaritan Regional Medical Center, Phoenix, Arizona, USA.
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MeSH Terms
Antidotes / administration & dosage,  pharmacokinetics*
Antihypertensive Agents / pharmacokinetics,  toxicity
Cyanides / blood,  pharmacokinetics,  poisoning,  toxicity*
Disease Models, Animal
Fetal Blood / metabolism
Fetal Diseases / blood,  metabolism,  prevention & control
Maternal-Fetal Exchange*
Nitroprusside / pharmacokinetics,  toxicity
Thiosulfates / administration & dosage,  blood,  pharmacokinetics*
Reg. No./Substance:
0/Antidotes; 0/Antihypertensive Agents; 0/Cyanides; 0/Thiosulfates; 15078-28-1/Nitroprusside; 7772-98-7/sodium thiosulfate

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