Document Detail

The lack of routine surveillance of parvovirus B19 infection in pregnancy prevents an accurate understanding of this regular cause of fetal loss and the risks posed by occupational exposure.
MedLine Citation:
PMID:  22977072     Owner:  NLM     Status:  Publisher    
In Europe fetal loss due to parvovirus B19 (B19V) is under-reported and a poorly addressed occupational risk to pregnant women. This is exemplified internationally, where it was unmentioned in the last 2 ECDC annual surveillance reports or its 2009 special report on infections in pregnancy. To assess this potential for under estimating B19V fetal loss in pregnancy, we undertook a systematic review of practice in Northern Ireland in the management and reporting of B19V infections over a 12 month period of heightened transmission, 1 of 6 observed in a span of 9 years. Pregnant and non-pregnant women presented with symptomatic infection in 24% and 93% of confirmed B19V infections respectively, with no difference in viral loads. There was under investigation of viral causes of fetal loss, with only 143/2739 (5%) tested for B19V, and a failure to follow-up most non-immune women tested following rash contact. Occupational exposure was recorded in 31/60 (51.6%) pregnancies audited following rash exposure, the majority teachers or day care workers. Against a background seroprevalence of 66.5% immunity in women of child-bearing years, two patterns of infection were identified. Firstly, pregnant women investigated for a rash or exposure to slapped cheek syndrome, where an infection incidence of 18% was observed, resulted in 42 confirmed infections, all proceeding to healthy term deliveries. Secondly, pregnant women with unsuspected infection had 6 cases of confirmed B19V fetal loss, including 4 of 22 (18%) diagnosed at autopsy, of which 3 were non-hydropic. While many studies have reported B19V fetal loss in pregnancy, there are no robust public health surveillance figures to draw on. That all 6 confirmed fetal losses came from the small number of miscarriages / stillbirths investigated, 143 out of 2739, suggests inadequate follow-up of those pregnancies where B19V related fetal loss may be most common and supports the need for enhanced surveillance pilots to address this significant gap in public health knowledge.
Alison Watt; Martin Brown; Melanie Pathiraja; Akila Anbazhagan; Peter V Coyle
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-13
Journal Detail:
Title:  Journal of medical microbiology     Volume:  -     ISSN:  1473-5644     ISO Abbreviation:  J. Med. Microbiol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0224131     Medline TA:  J Med Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1 Regional Virus Laboratory, Royal Victoria Hospital, Belfast Trust.;
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