Document Detail


The lack of relationship between acetylator phenotype and idiopathic systemic lupus erythematosus in a South-east Asian population: a study of Indians, Malays and Malaysian Chinese.
MedLine Citation:
PMID:  2257457     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An association of idiopathic systemic lupus erythematosus (ISLE) with genetically determined N-acetylation polymorphism has been suspected from previous studies, mainly on Caucasian populations in which there is an approximate incidence of 50% of slow and rapid acetylators. The present study is of the incidence of ISLE and acetylator status in a mixed population of Malaysia. The results did not support an association between ISLE and acetylator status: the frequencies of slow acetylators in the ISLE patients who were Malaysian Chinese and Malay were 13 and 38% respectively. This did not differ significantly from the respective healthy groups (20 and 29%). The small number of Indians in the survey did not allow a valid comparison, but the figures did suggest a lack of association between ISLE and acetylator status.
Authors:
M L Ong; T G Mant; K Veerapen; D Fitzgerald; F Wang; M Manivasagar; J J Bosco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  29     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-01-25     Completed Date:  1991-01-25     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  462-4     Citation Subset:  AIM; IM    
Affiliation:
Guy's Hospital, London.
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MeSH Terms
Descriptor/Qualifier:
Acetylation
Adolescent
Adult
Asia, Southeastern / epidemiology
China / ethnology
Dapsone / diagnostic use
Female
Humans
India / ethnology
Lupus Erythematosus, Systemic / ethnology,  genetics*,  microbiology
Malaysia / ethnology
Male
Middle Aged
Phenotype
Time Factors
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
80-08-0/Dapsone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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