Document Detail

A lack of essential fatty acids as a possible cause of hyperactivity in children.
MedLine Citation:
PMID:  7196985     Owner:  NLM     Status:  MEDLINE    
The Hyperactive Children's Support Group (HCSG) in an organisation with over 70 branches in Britain devoted to helping such children and their families. We have carried out a detailed survey of the characteristics of many of our children and their families and have studied the literature in detail. We have come to the conclusion that many of these children have a deficiency of essential fatty acids (EFAs) either because they cannot metabolise linoleic acid normally, or because they cannot absorb EFAs normally from the gut, or because their EFA requirements are higher than normal. The main pieces of evidence are: 1. Most of the food constituents which cause trouble in these children are weak inhibitors of the conversion of EFAs to prostaglandins (PGs). 2. Boys are much more commonly effected than girls and males are known to have much higher requirements for EFAs than females. 3. A high proportion of our children have abnormal thirst and thirst is one of the cardinal signs of EFA deficiency. 4. Many of our children have eczema, allergies and asthma which some reports suggest can be alleviated by EFAs. 5. Many of our children are deficient in zinc which is required for conversion of EFAs to PGs. 6. Some of of our children are badly affected by wheat and milk which are known to give rise to exorphins in the gut which can block conversion of EFAs to PGE1. A preliminary study of EFA supplementation in a number of our children has given promising results. We hope that others with better facilities will be encouraged to test out this hypothesis.
I Colquhoun; S Bunday
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  7     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-11-22     Completed Date:  1981-11-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  673-9     Citation Subset:  IM    
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MeSH Terms
Dietary Carbohydrates
Fatty Acids, Essential / deficiency*
Hair / analysis
Hyperkinesis / etiology*,  physiopathology
Prostaglandins E / deficiency
Sex Factors
Zinc / analysis
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Fatty Acids, Essential; 0/Prostaglandins E; 7440-66-6/Zinc; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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