Document Detail

The laboratory school protocol: its origin, use, and new applications.
MedLine Citation:
PMID:  16840597     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: ADHD is the most common childhood psychiatric disorder, with impairments seen in home and academic settings. To investigate such impairments in a school-like setting, the laboratory school protocol (LSP) was developed at the University of California, Irvine. METHOD: This model provides a rigorously controlled environment to examine pharmacodynamic and pharmacokinetic aspects of responses to treatment. A key principle of this methodology is to exercise tight control of the timing and context of measurements by establishing a cycle of activities repeated across each study day. In addition, the LSP approach has been extended to both younger and older populations than the typically studied school-aged group. This extension requires corresponding modifications in measures to characterize drug efficacy and to allow evaluation of ADHD symptoms in a highly standardized setting. RESULTS: This article provides guidelines for employing the LSP for the assessment of medication effects for both preschool and adolescent/adult populations. CONCLUSION: The LSP can be modified to form either an Adult Workplace Environment or a Preschool Assessment Laboratory.
Sharon B Wigal; Timothy L Wigal
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of attention disorders     Volume:  10     ISSN:  1087-0547     ISO Abbreviation:  J Atten Disord     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-14     Completed Date:  2006-10-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9615686     Medline TA:  J Atten Disord     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  92-111     Citation Subset:  IM    
University of California, Irvine, Child Development Center, CA 92612, USA.
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MeSH Terms
Attention Deficit Disorder with Hyperactivity / drug therapy*
Central Nervous System Stimulants / pharmacology*,  therapeutic use*
Child, Preschool
Cognition / drug effects
Psychomotor Performance / drug effects*
Reaction Time / drug effects
School Health Services*
Reg. No./Substance:
0/Central Nervous System Stimulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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