Document Detail

A laboratory evaluation of the Kowa laser flare-cell meter for the study of uveitis.
MedLine Citation:
PMID:  1427139     Owner:  NLM     Status:  MEDLINE    
The Kowa FC-1000 laser flare-cell meter (LFCM) has been described as an instrument which will objectively quantify inflammation of the anterior chamber of the eye. We evaluated the LFCM using the intravenous endotoxin-induced uveitis (EIU) rabbit model of ocular inflammation. In vitro flare and cell calibration measurements utilizing bovine serum albumin (BSA) and latex particles, respectively, were also performed. A linear relationship between the flare measurements and BSA concentrations was noted. In addition, the time course of the LFCM flare count in EIU was comparable to previously published fluorophotometric data. However, the LFCM reported cells in the anterior chamber of the EIU rabbits despite negative cytology and histology results. The LFCM also recorded cells in BSA solutions which contained neither cells nor latex particles. Our results suggest that although the LFCM may be useful for evaluating flare, its cell measurements are not accurate in cases of severe uveitis.
M Ni; J N Bloom; S Lele; C Sotelo-Avila
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  230     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-22     Completed Date:  1992-12-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  547-51     Citation Subset:  IM    
Department of Ophthalmology, Bethesda Eye Institute, St. Louis, Missouri 63110.
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MeSH Terms
Anterior Chamber / pathology
Aqueous Humor
Bacterial Toxins
Cell Count
Disease Models, Animal
Evaluation Studies as Topic
Ophthalmology / instrumentation*
Uveitis, Anterior / chemically induced,  pathology*
Reg. No./Substance:
0/Bacterial Toxins; 0/Endotoxins; 0/Enterotoxins; 0/salmonella toxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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