| 123/125I-labelled 2-iodo-L: -phenylalanine and 2-iodo-D: -phenylalanine: comparative uptake in various tumour types and biodistribution in mice. | |
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MedLine Citation:
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PMID: 16572305 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: In vitro in the R1M cell model and in vivo in the R1M tumour-bearing athymic model, both [(123)I]-2-iodo-L: -phenylalanine and [(123)I]-2-iodo-D: -phenylalanine have shown promising results as tumour diagnostic agents for SPECT. In order to compare these two amino acid analogues and to examine whether the observed characteristics could be generalised, both isomers were evaluated in various tumour models. METHODS: Transport type characterisation in vitro in A549, A2058, C6, C32, Capan2, EF43fgf4, HT29 and R1M cells with [(123)I]-2-iodo-L: -phenylalanine was performed using the method described by Shotwell et al. Subsequently, [(123)I]-2-iodo-L: -phenylalanine and [(123)I]-2-iodo-D: -phenylalanine tumour uptake and biodistribution were evaluated using dynamic planar imaging and/or dissection in A549, A2058, C6, C32, Capan2, EF43fgf4, HT29 and R1M inoculated athymic mice. Two-compartment blood modelling of the imaging results was performed. RESULTS: In vitro testing demonstrated that [(123)I]-2-iodo-L: -phenylalanine was transported in all tumour cell lines by LAT1. In all tumour models, the two amino acid analogues showed the same general biodistribution characteristics: high and specific tumour uptake and renal tracer clearance. Two-compartment modelling revealed that the D: -isomer showed a faster blood clearance together with a faster distribution to the peripheral compartment in comparison with [(123)I]-2-iodo-L: -phenylalanine. CONCLUSION: [(123)I]-2-iodo-L: -phenylalanine and its D: -isomer are promising tumour diagnostic agents for dynamic planar imaging. They showed a high and similar uptake in all tested tumours. [(123)I]-2-iodo-D: -phenylalanine showed better tracer characteristics concerning radiation dose to other organs. |
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Authors:
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Veerle Kersemans; Bart Cornelissen; Ken Kersemans; Matthias Bauwens; Rudi A Dierckx; Bart De Spiegeleer; John Mertens; Guido Slegers |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-30 |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 33 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-25 Completed Date: 2006-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: 919-27 Citation Subset: IM |
Affiliation:
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Laboratory for Radiopharmacy, Universiteit Gent, Harelbekestraat 72, B-9000, Gent, Belgium. veerle.kersemans@utoronto.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma / metabolism* Cell Line, Tumor Female Humans Isotope Labeling Metabolic Clearance Rate Mice Organ Specificity Phenylalanine / analogs & derivatives*, diagnostic use, pharmacokinetics Radiopharmaceuticals / diagnostic use, pharmacokinetics Tissue Distribution Tomography, Emission-Computed, Single-Photon / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 1991-81-7/4-iodophenylalanine; 63-91-2/Phenylalanine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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