Document Detail


l-3-n-Butylphthalide ameliorates beta-amyloid-induced neuronal toxicity in cultured neuronal cells.
MedLine Citation:
PMID:  18328624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
l-3-n-Butylphthalide (l-NBP), as an anti-cerebral ischemia agent, has been shown to have therapeutic effects on learning and memory deficits induced by chronic cerebral hypoperfusion and Abeta intracerebroventricular infusion in rats. In the present study, we investigated the neuroprotective effects of l-NBP on beta-amyloid (Abeta)25-35-induced neuronal death/apoptosis and potential mechanisms in rat hippocampal neurons and human neuroblastoma SH-SY5Y cells. Abeta25-35 significantly reduced cell viability and increased the number of apoptotic-like cells, indicating that Abeta25-35-induced neurotoxicity. In addition, tau protein hyperphosphorylation was found to increase after Abeta exposure. All of these phenotypes induced by Abeta25-35 were markedly reversed by l-NBP. Pretreatment with l-NBP prior to Abeta25-35 exposure significantly elevated cell viability, and reduced Abeta25-35-induced nuclear fragmentation and early apoptosis. Furthermore, immunoreactivity for hyperphosphorylation tau protein was significantly decreased by l-NBP treatment. Our results suggest that l-NBP may protect neurons against Abeta-induced neurotoxicity via inhibiting tau protein hyperphosphorylation.
Authors:
Ying Peng; Changhong Xing; Cynthia A Lemere; Guiquan Chen; Ling Wang; Yipu Feng; Xiaoliang Wang
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Publication Detail:
Type:  Journal Article     Date:  2008-02-14
Journal Detail:
Title:  Neuroscience letters     Volume:  434     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-21     Completed Date:  2008-06-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  224-9     Citation Subset:  IM    
Affiliation:
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1, Xiannongtan Street, Xuanwu District, Beijing 100050, China.
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MeSH Terms
Descriptor/Qualifier:
Amyloid beta-Protein / toxicity*
Animals
Apium graveolens
Apoptosis / drug effects
Benzofurans / pharmacology*
Brain Neoplasms
Cell Line, Tumor
Cell Survival / drug effects
Drug Interactions
Hippocampus / cytology
Humans
Neuroblastoma
Neurons / cytology*,  drug effects*
Neuroprotective Agents / pharmacology*
Peptide Fragments / toxicity*
Plant Extracts / pharmacology
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Benzofurans; 0/CML-1 plant extract; 0/Neuroprotective Agents; 0/Peptide Fragments; 0/Plant Extracts; 0/amyloid beta-protein (25-35); 6066-49-5/3-n-butylphthalide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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