Document Detail

The kynurenate analog SZR-72 prevents the nitroglycerol-induced increase of c-fos immunoreactivity in the rat caudal trigeminal nucleus: comparative studies of the effects of SZR-72 and kynurenic acid.
MedLine Citation:
PMID:  18541319     Owner:  NLM     Status:  MEDLINE    
Administration of nitroglycerol in a migraine model results in an increased number of c-fos-expressing secondary sensory neurons in the caudal trigeminal nucleus. Since synapses between first- and second-order trigeminal neurons are mediated by excitatory amino acids, NMDA receptors are inhibited by kynurenic acid, though this crosses the blood-brain barrier only poorly. Systemic treatment of rats with SZR-72, a newly synthetized kynurenic acid analog, diminished the nitroglycerol-induced increase of c-fos immunoreactivity in the brain stem highly significantly, while treatment with kynurenic acid resulted in a significantly smaller decrease, proving that SZR-72 is much more effective than kynurenic acid.
E Knyihar-Csillik; A Mihaly; B Krisztin-Peva; H Robotka; I Szatmari; F Fulop; J Toldi; B Csillik; L Vecsei
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-05-02
Journal Detail:
Title:  Neuroscience research     Volume:  61     ISSN:  0168-0102     ISO Abbreviation:  Neurosci. Res.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-11-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500749     Medline TA:  Neurosci Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
Department of Neurology, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, 6 Semmelweis utca, H-6726 Szeged, Hungary.
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MeSH Terms
Cell Count
Drug Interactions
Excitatory Amino Acid Antagonists / pharmacology*
Kynurenic Acid / analogs & derivatives*,  pharmacology*
Neurons / drug effects,  metabolism
Nitroglycerin / pharmacology*
Proto-Oncogene Proteins c-fos / metabolism*
Rats, Wistar
Trigeminal Caudal Nucleus / cytology,  drug effects*,  metabolism
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 0/Proto-Oncogene Proteins c-fos; 0/SZR 72; 492-27-3/Kynurenic Acid; 55-63-0/Nitroglycerin

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