| The kinin system in hypertensive pathophysiology. | |
| | |
MedLine Citation:
|
PMID: 22527353 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cardiovascular diseases are the prime cause of death in the world. The kallikrein-kinin system has been implicated in the pathophysiology of the vascular smooth muscle and cardiac dysfunctions. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischemia, myocardial infarction and left ventricular hypertrophy, have suggested that the reduced activity of the local kallikrein-kinin system may be instrumental for the induction of cardiovascular-related diseases. The cardioprotective actions of the angiotensin-converting enzyme inhibitors are primarily dependent on protecting the kinin-forming components, which may cause regression of the left ventricular hypertrophy in hypertensive situations. The ability of kallikrein gene delivery to produce a wide spectrum of beneficial effects makes it an excellent candidate in treating hypertension, cardiovascular and renal diseases. In addition, stable kinin agonists may also be available in the future as therapeutic agents for cardiovascular and renal disorders. |
| | |
Authors:
|
Jagdish N Sharma |
Related Documents
:
|
22826653 - Ventricular fibrillation during coronary angiography in a patient with left dominant co... 676733 - On cerebral infarction in childhood and adolescence. 9327313 - Hemodynamic benefit of optimizing atrioventricular delay after cardiopulmonary bypass. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-4-17 |
Journal Detail:
|
Title: Inflammopharmacology Volume: - ISSN: 1568-5608 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-4-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9112626 Medline TA: Inflammopharmacology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Health Sciences Center, Kuwait University, P.O. Box 24923, 13110, Safat, Kuwait, j.n.sharma@hsc.edu.kw. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucif...
Next Document: Matched Sibling Versus Matched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation in Child...