| The kinetics of cohesive powder de-agglomeration from three inhaler devices. | |
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MedLine Citation:
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PMID: 21963469 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: The purpose of the current investigation is to understand the kinetics of de-agglomeration (k(d)) of micronised salbutamol sulphate (SS) and lactohale 300 (LH300) under varying air flow rates (30-180lmin(-1)) from three dry powder inhaler devices (DPIs), Rotahaler(®) (RH), Monodose Inhaler(®) (MI) and Handihaler(®) (HH). RESULTS: Cumulative fine particle mass vs. time profiles were obtained from the powder concentration, emitted mass and volume percent <5.4μm, embedded in the particle size distributions of the aerosol at specific times. The rate of de-agglomeration (k(d)), estimated from non-linear least squares modelling, increased with increasing air flow rates. The k(d)vs. air flow rate profiles of SS and LH300 were significantly different at high air flow rates. The k(d) was highest from RH and lowest from MI. Differences in k(d) between the devices were related to device mode of operation while the differences between the materials were due to the powder bed structure. CONCLUSION: This approach provided a methodology to measure the rate constant for cohesive powder de-agglomeration following aerosolisation from commercial devices and an initial understanding of the influence of device, air flow rate and material on these rate constants. |
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Authors:
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Srinivas Ravindra Babu Behara; Ian Larson; Paul Kippax; David A V Morton; Peter Stewart |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-21 |
Journal Detail:
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Title: International journal of pharmaceutics Volume: - ISSN: 1873-3476 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804127 Medline TA: Int J Pharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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