| A kinetic study on the regeneration of Candida albicans protoplasts in the presence of cell wall synthesis inhibitors. | |
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MedLine Citation:
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PMID: 8359679 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aculeacin A and papulacandin B block cell wall regeneration in Candida albicans protoplasts at an intermediate step in which the protoplasts have not yet synthesized the rigid structure of the cell wall and are therefore still osmotically sensitive. In the presence of the antibiotics, total synthesis of glucan is not significantly lowered with respect to control cells, although most of it appears either in the culture medium or in the regenerating wall as alkali-soluble glucan. Thus, it is proposed that echinocandins (such as aculeacin A) and papulacandins may not inhibit glucan synthesis per se but instead inhibit its incorporation into the supramolecular organization of the cell wall. |
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Authors:
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J Font de Mora; E Herrero; R Sentandreu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEMS microbiology letters Volume: 111 ISSN: 0378-1097 ISO Abbreviation: FEMS Microbiol. Lett. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-09-29 Completed Date: 1993-09-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7705721 Medline TA: FEMS Microbiol Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 43-7 Citation Subset: IM |
Affiliation:
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Seccio Departamental de Microbiologia, Universitat de Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aminoglycosides* Anti-Bacterial Agents / pharmacology* Antifungal Agents / pharmacology* Candida albicans / drug effects, physiology* Cell Wall / drug effects, physiology* Kinetics Peptides, Cyclic* Protoplasts / drug effects, physiology Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Aminoglycosides; 0/Anti-Bacterial Agents; 0/Antifungal Agents; 0/Peptides, Cyclic; 58814-86-1/aculeacin A; 61032-80-2/papulacandin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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