Document Detail


A kinetic analysis of lymphocyte 5'-nucleotidase in B-cell clones from control subjects and patients with primary hypogammaglobulinaemia.
MedLine Citation:
PMID:  2561998     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The affinity of lymphocyte 5'-nucleotidase (5NT) for its substrate adenosine monophosphate (AMP) was studied in Epstein-Barr virus immortalized B-lymphocyte clones from healthy controls and patients with primary hypogammaglobulinaemia. Km values for AMP for 5NT in most of the patient clones were found to be significantly increased compared to B-cell clones from normal subjects, whereas Vmax values were within the normal range.
Authors:
S E Barwick; M Malkovsky; A D Webster; T J Peters
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical & laboratory immunology     Volume:  30     ISSN:  0141-2760     ISO Abbreviation:  J Clin Lab Immunol     Publication Date:  1989 Nov 
Date Detail:
Created Date:  1990-10-22     Completed Date:  1990-10-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7808987     Medline TA:  J Clin Lab Immunol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Affiliation:
Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, UK.
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MeSH Terms
Descriptor/Qualifier:
5'-Nucleotidase / analysis*
Adenosine Monophosphate / metabolism
Agammaglobulinemia / enzymology*,  pathology
B-Lymphocytes / enzymology*,  pathology
Cell Line, Transformed
Herpesvirus 4, Human
Humans
Kinetics
Chemical
Reg. No./Substance:
61-19-8/Adenosine Monophosphate; EC 3.1.3.5/5'-Nucleotidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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