| RhoA/Rho kinase: a novel therapeutic target in diabetic complications. | |
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MedLine Citation:
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PMID: 21034566 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To reveal the roles of Rho kinase (ROCK) in the mechanisms of complications in diabetes by reviewing the correlations between ROCK and related complications in diabetes. DATA SOURCES: The data used in the present article were mainly from PubMed with relevant English articles published from 1998 to 2010. The search terms were "ROCK" and "diabetes". STUDY SELECTION: Original articles including the roles of ROCK or its inhibitors in diabetic complications and review articles about the biological character of ROCK were selected. RESULTS: The activity and expression of ROCK were up-regulated in the models of type 1 or type 2 diabetes animals and the cultured cells with concentrations of high glucose, ROCK activation was associated with the development or progression of complications in diabetes. Inhibition of RhoA/ROCK pathway prevented or ameliorated the pathologic changes of diabetic complications, and ROCK has been regarded as a key target for treatment of these complications. CONCLUSION: RhoA/ROCK signaling plays important roles in the pathogenesis of long-term complications in diabetes and ROCK inhibitors are becoming a promising solution to treatments of complications in diabetes. |
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Authors:
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Hong Zhou; Yong-jun Li |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese medical journal Volume: 123 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-11-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 2461-6 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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