| The key role of vitamin A in spermatogenesis. | |
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MedLine Citation:
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PMID: 20364093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. These changes over time and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, respectively. In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave. |
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Authors:
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Cathryn A Hogarth; Michael D Griswold |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-04-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 120 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-04-21 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 956-62 Citation Subset: AIM; IM |
Affiliation:
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School of Molecular Biosciences, Washington State University, Pullman, WA 99164-7520, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Follicle Stimulating Hormone / physiology Humans Male Meiosis Seminiferous Epithelium / physiology Sertoli Cells / physiology Spermatogenesis / physiology* Testosterone / physiology Vitamin A / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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HD 10808-33/HD/NICHD NIH HHS; U54 42454//PHS HHS |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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