Document Detail

The key role of vitamin A in spermatogenesis.
MedLine Citation:
PMID:  20364093     Owner:  NLM     Status:  MEDLINE    
Spermatogenesis in adult mammals is highly organized, with the goal being continual sperm production. Vertebrate testes are arranged into recurring cellular associations that vary with time and distance along the tubule. These changes over time and distance are designated the cycle of the seminiferous epithelium and the spermatogenic wave, respectively. In this Review, we briefly outline the roles that follicle-stimulating hormone (FSH) and testosterone play in regulating spermatogenesis and describe our current understanding of how vitamin A regulates germ cell differentiation and how it may lead to the generation of both the cycle of the seminiferous epithelium and the spermatogenic wave.
Cathryn A Hogarth; Michael D Griswold
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-04-01
Journal Detail:
Title:  The Journal of clinical investigation     Volume:  120     ISSN:  1558-8238     ISO Abbreviation:  J. Clin. Invest.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-04-21     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7802877     Medline TA:  J Clin Invest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  956-62     Citation Subset:  AIM; IM    
School of Molecular Biosciences, Washington State University, Pullman, WA 99164-7520, USA.
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MeSH Terms
Cell Differentiation
Follicle Stimulating Hormone / physiology
Seminiferous Epithelium / physiology
Sertoli Cells / physiology
Spermatogenesis / physiology*
Testosterone / physiology
Vitamin A / physiology*
Grant Support
HD 10808-33/HD/NICHD NIH HHS; U54 42454//PHS HHS
Reg. No./Substance:
11103-57-4/Vitamin A; 58-22-0/Testosterone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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