| The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway. | |
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MedLine Citation:
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PMID: 21371020 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition. |
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Authors:
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Sharon S McDaniel; Nicholas R Rensing; Liu Lin Thio; Kelvin A Yamada; Michael Wong |
Publication Detail:
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Type: Journal Article Date: 2011-03-03 |
Journal Detail:
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Title: Epilepsia Volume: 52 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-14 Completed Date: 2011-05-09 Revised Date: 2012-03-07 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: e7-11 Citation Subset: IM |
Copyright Information:
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Wiley Periodicals, Inc. © 2011 International League Against Epilepsy. |
Affiliation:
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Department of Neurology and the Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Epilepsy / diet therapy*, genetics*, pathology Gene Expression / genetics Hippocampus / pathology Ketogenic Diet Liver / pathology Protein Kinases / genetics Rats Rats, Sprague-Dawley Signal Transduction / genetics Status Epilepticus / genetics TOR Serine-Threonine Kinases / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS056872-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.7.-/Protein Kinases; EC 2.7.1.-/AMP-activated protein kinase kinase; EC 2.7.1.1/TOR Serine-Threonine Kinases; EC 2.7.1.1/mTOR protein, rat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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