Document Detail


The ketogenic diet in treatment of two adults with prolonged nonconvulsive status epilepticus.
MedLine Citation:
PMID:  19845731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolonged status epilepticus (SE) can be refractory to conventional interventions, with high rates of subsequent morbidity and mortality. A high fat, low protein, low carbohydrate ketogenic diet (KD) has been used successfully to treat intractable epilepsy. However, its possible role in prolonged SE has not been well described. We report successful use of the KD in two adult patients with prolonged nonconvulsive SE (NCSE) refractory to multiple other interventions. Our observations suggest induction of ketosis may be a novel strategy to safely and effectively treat status in adults even after weeks to months of refractory seizures. Although there are few data regarding the use of the ketogenic diet in the treatment of adult epilepsy syndromes, it may be an option for the treatment of adults with refractory, prolonged SE.
Authors:
Courtney J Wusthoff; Sarah M Kranick; James F Morley; A G Christina Bergqvist
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-10-20
Journal Detail:
Title:  Epilepsia     Volume:  51     ISSN:  1528-1167     ISO Abbreviation:  Epilepsia     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-08-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1083-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA. wusthoff@email.chop.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Ketogenic Diet / methods*
Male
Status Epilepticus / diet therapy*,  physiopathology
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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