Document Detail

The ketogenic diet in refractory epilepsy: the experience of Children's Hospital of Pittsburgh.
MedLine Citation:
PMID:  10752008     Owner:  NLM     Status:  MEDLINE    
The ketogenic diet appears to be effective in reducing seizure frequency in patients with epilepsy refractory to antiepileptic drug therapy. Reported seizure frequencies before and after the diet was initiated were obtained for 48 patients started on the ketogenic diet between December 1994 and January 1998 at Children's Hospital of Pittsburgh. The majority of patients (71%) were able to achieve > or = 50% reduction in seizure activity. Of these, more than half (53%) had > 90% reduction in seizures after 45 days of diet therapy. Complications included gastrointestinal complaints and infrequent lipid abnormalities. The ketogenic diet appears to be an effective method of treatment for children with epilepsy refractory to drug therapy.
N G Katyal; A N Koehler; B McGhee; C M Foley; P K Crumrine
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pediatrics     Volume:  39     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-06-20     Completed Date:  2000-06-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  AIM; IM    
Department of Clinical Nutrition, Children's Hospital of Pittsburgh, PA 15213, USA.
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MeSH Terms
Child, Preschool
Dietary Carbohydrates / administration & dosage
Dietary Fats / administration & dosage
Dietary Proteins / administration & dosage
Epilepsy / diet therapy*
Follow-Up Studies
Ketones / metabolism*
Lipid Metabolism
Treatment Failure
Vitamins / therapeutic use
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Dietary Proteins; 0/Ketones; 0/Vitamins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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