| A ketogenic diet does not impair rat behavior or long-term potentiation. | |
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MedLine Citation:
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PMID: 20132289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically.We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie-restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD-fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired-pulse modulation (PPM) and long-term potentiation (LTP) in the medial perforant path in vivo. KD-fed rats performed similarly to SD-fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity. |
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Authors:
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Liu Lin Thio; Nicholas Rensing; Susan Maloney; David F Wozniak; Chengjie Xiong; Kelvin A Yamada |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsia Volume: 51 ISSN: 1528-1167 ISO Abbreviation: Epilepsia Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-10-08 Completed Date: 2010-10-22 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: United States |
Other Details:
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Languages: eng Pagination: 1619-23 Citation Subset: IM |
Affiliation:
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Department of Neurology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. thiol@neuro.wustl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Hydroxybutyric Acid
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blood Analysis of Variance Animals Animals, Newborn Behavior, Animal / drug effects*, physiology Conditioning, Classical / drug effects Dietary Fats / administration & dosage, pharmacology* Excitatory Postsynaptic Potentials / drug effects Fear / drug effects Long-Term Potentiation / drug effects*, physiology Motor Activity / drug effects Patch-Clamp Techniques Prefrontal Cortex / drug effects*, physiology* Rats Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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C06 RR015502/RR/NCRR NIH HHS; C06 RR015502-01/RR/NCRR NIH HHS; DK20579/DK/NIDDK NIH HHS; NS32636/NS/NINDS NIH HHS; NS42774/NS/NINDS NIH HHS; NS58597/NS/NINDS NIH HHS; P01 NS032636-08/NS/NINDS NIH HHS; P30 NS057105/NS/NINDS NIH HHS; P30 NS057105-01/NS/NINDS NIH HHS; P60 DK020579-23/DK/NIDDK NIH HHS; R21 NS042744-01A2/NS/NINDS NIH HHS; R21 NS058597-01/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 300-85-6/3-Hydroxybutyric Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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