| The kallikrein--kinin system in blood vessels. | |
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MedLine Citation:
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PMID: 1462850 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have previously reported that vascular tissue contains kallikrein and kallikrein mRNA. We can now show that kallikrein is present throughout the vascular tree and is released from arterial and venous rings incubated "in vitro". Using the isolated perfused rat hindquarters as a model, we found that kallikrein appeared in the perfusate in concentrations that increased linearly with time. Treatment with puromycin inhibited kallikrein release by 87% (p < 0.01), these data suggest that kallikrein is synthesized and released by the vascular wall. Local generation of kinins (autocrine/paracrine system) may contribute to the regulation of vascular homeostasis. |
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Authors:
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H L Nolly; M C Lama; O A Carretero; A G Scicli |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Agents and actions. Supplements Volume: 38 ( Pt 3) ISSN: 0379-0363 ISO Abbreviation: Agents Actions Suppl. Publication Date: 1992 |
Date Detail:
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Created Date: 1993-01-13 Completed Date: 1993-01-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801014 Medline TA: Agents Actions Suppl Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 1-9 Citation Subset: IM |
Affiliation:
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Hypertension and Vascular Res. Div., Henry Ford Hospital, Detroit, MI. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta, Abdominal / enzymology Aorta, Thoracic / enzymology Arteries / enzymology* Hindlimb / blood supply Kallikreins / metabolism* Kinetics Male Muscle, Smooth, Vascular / enzymology* Perfusion Rats Rats, Wistar Veins / enzymology* Vena Cava, Inferior / enzymology |
| Chemical | |
Reg. No./Substance:
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EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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