Document Detail


The joint toxic action of perchloroethylene with benzene or toluene in rats.
MedLine Citation:
PMID:  1129807     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The joint toxic action of mixtures of perchloroethylene with benzene or toluene was tested at five dose levels for each of six binary combinations with 20 rats per dose. LD50 data with 95% fiducial limits are reported for each mixture and tests for additive joint toxicity were made. The results indicate that the mixtures of perchloroethylene and benzene gave values for the LD50 which were slightly less than additive while perchloroethylene and toluene mixtures had LD50 values which could not be predicted by an additive model.
Authors:
R J Withey; J W Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  4     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1975  
Date Detail:
Created Date:  1975-08-04     Completed Date:  1975-08-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  5-15     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzene / toxicity*
Drug Interactions
Lethal Dose 50
Male
Models, Biological
Rats
Tetrachloroethylene / toxicity*
Toluene / toxicity*
Chemical
Reg. No./Substance:
108-88-3/Toluene; 127-18-4/Tetrachloroethylene; 71-43-2/Benzene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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