Document Detail


The i.v. infusion of mannitol decreases airway responsiveness to methacholine in asthma.
MedLine Citation:
PMID:  17289447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bronchial asthma and chronic obstructive pulmonary disease (COPD) are characterized by airway inflammation and oedema. The oedema of the airway wall may contribute to airway narrowing and hyperresponsiveness by increasing airway wall thickness, by altering airway compliance, or by impairing the transmission of the lung elastic recoil to the airway smooth muscle (ASM). We hypothesized that the i.v. infusion of mannitol, an osmotic diuretic, would reduce the water content of the airway wall in asthma and COPD, thus decreasing airway responsiveness to methacholine (MCh). In eight asthmatic and in six COPD patients, airway responsiveness to MCh, lung volumes and lung mechanics were measured before and after infusion of mannitol. In the asthmatics, mannitol decreased airway responsiveness to MCh and lung elastic recoil. In the COPD patients, no differences were recorded after mannitol infusion. These data suggest that the airway wall oedema, in asthma, has an impact on airway responsiveness to MCh. The differential effect of mannitol in asthma versus COPD, may relate to the specific pathologic features of the diseases.
Authors:
Giuseppe Valerio; Francesco G Salerno; Pierluigi Bracciale
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Publication Detail:
Type:  Journal Article     Date:  2007-01-12
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  156     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-05-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  374-7     Citation Subset:  IM    
Affiliation:
Divisione di Pneumologia, Ospedale Ninetto Melli, San Pietro Vernotico, Via Lecce 246-72027, San Pietro Vernotico, Brindisi, Italy. div.pneumo@tiscali.it
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance / physiology
Asthma / drug therapy*,  physiopathology
Bronchoconstrictor Agents / antagonists & inhibitors*,  therapeutic use*
Diuretics / administration & dosage,  adverse effects*
Humans
Infusions, Intravenous
Male
Mannitol / administration & dosage,  adverse effects*
Methacholine Chloride / antagonists & inhibitors*,  therapeutic use*
Middle Aged
Osmotic Pressure
Pulmonary Disease, Chronic Obstructive / physiopathology
Respiratory Function Tests
Respiratory Mechanics / physiology
Chemical
Reg. No./Substance:
0/Bronchoconstrictor Agents; 0/Diuretics; 62-51-1/Methacholine Chloride; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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