Document Detail


Is it worth while changing clinically stable schizophrenic out-patients with mild to moderate residual symptoms and/or side effects from conventional to atypical antipsychotics? A prospective, randomised study with olanzapine.
MedLine Citation:
PMID:  15589715     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty clinically stable, schizophrenic outpatients, suffering from residual schizophrenic symptoms and/or neurological side effects, were randomised to either continue their conventional neuroleptic(s) or change it to olanzapine. After 12 weeks patients on olanzapine exhibited significant improvement in neurological side effects and psychotic symptomatology as compared to patients on conventional antipsychotics.
Authors:
Björn Appelberg; Katinka Tuisku; Grigori Joffe
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European psychiatry : the journal of the Association of European Psychiatrists     Volume:  19     ISSN:  0924-9338     ISO Abbreviation:  Eur. Psychiatry     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-05-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9111820     Medline TA:  Eur Psychiatry     Country:  France    
Other Details:
Languages:  eng     Pagination:  516-8     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Helsinki University Central Hospital, POB 590, 00029 Hus, Finland. bjorn.appelberg@helsinki.fi
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MeSH Terms
Descriptor/Qualifier:
Adult
Ambulatory Care*
Antipsychotic Agents / adverse effects*
Benzodiazepines / therapeutic use*
Chlorpromazine / therapeutic use
Female
Humans
Male
Middle Aged
Prospective Studies
Schizophrenia / diagnosis,  therapy*
Chemical
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 50-53-3/Chlorpromazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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