Document Detail

Is it time to re-evaluate our use of acetaminophen in certain sub-groups of pregnant women?
MedLine Citation:
PMID:  19031271     Owner:  NLM     Status:  MEDLINE    
New insight into the pharmacological mechanisms of acetaminophen raises questions about its possible safety in certain subgroups of pregnant women. Recent focus on acetaminophen's ability to modulate prostaglandin synthesis may require modification of its ubiquitous use in pregnancy. Further basic science, epidemiologic and clinical studies are required to explore the interaction of acetaminophen with placentation leading to vascular pathologic conditions during pregnancy.
Carolyn M Zelop
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  21     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  761-2     Citation Subset:  IM    
Saint Francis Hospital and Medical Centre, Hartford, Connecticut 06105, USA.
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MeSH Terms
Acetaminophen / adverse effects,  contraindications*
Analgesics, Non-Narcotic / adverse effects,  contraindications*
Epoprostenol / metabolism
Pre-Eclampsia / etiology*
Reg. No./Substance:
0/Analgesics, Non-Narcotic; 103-90-2/Acetaminophen; 35121-78-9/Epoprostenol

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