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Is it time for hepcidin to join the diagnostic toolkit for iron deficiency?
MedLine Citation:
PMID:  22475284     Owner:  NLM     Status:  In-Data-Review    
Evaluation of: van Santen S, van Dongen-Lases EC, de Vegt F et al. Hepcidin and hemoglobin content parameters in the diagnosis of iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum. 63(12), 3672-3680 (2011). The diagnostic value of hepcidin, the master regulator of iron metabolism, as an index of iron status is being intensively investigated. van Santen et al. have reported the value of hepcidin as a test for iron deficiency in both noninflamed and inflamed anemic patients with rheumatoid arthritis. Their data show that serum hepcidin identifies iron deficiency in anemic rheumatoid arthritis patients. Based on these results, the authors offer cutoffs for hepcidin and propose an algorithm to diagnose iron deficiency in this setting. This study provides insight into the physiology of hepcidin regulation in patients with coexisting iron deficiency and inflammation.
Sant-Rayn Pasricha
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of hematology     Volume:  5     ISSN:  1747-4094     ISO Abbreviation:  Expert Rev Hematol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485942     Medline TA:  Expert Rev Hematol     Country:  England    
Other Details:
Languages:  eng     Pagination:  153-5     Citation Subset:  IM    
Nossal Institute for Global Health, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Victoria, Australia and Thalassaemia Services Victoria, Southern Health, Clayton, Victoria, Australia.
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