| Is it possible to predict the long-term response to venlafaxine with the use of biological markers and psychophysiological methods? | |
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MedLine Citation:
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PMID: 17049998 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The present study investigated whether it is possible to predict the medium term response to venlafaxine using biological markers and psychophysiological methods. MATERIAL: Fourteen (14) patients aged 21-60 years suffering from Major Depression according to DSM-IV were included in the study. METHODS: The SCAN v 2.0 and the IPDE were used to assist clinical diagnosis. Patients were investigated with electrooculogram (EOG), Pattern-Reversal Visual Evoked Potentials (PR-VEPs), Dexamethasone Suppression Test (DST), D-fenfluramine Challenge Test, and brain Single Photon Emission Tomography (SPECT). Venlafaxine 150-225 mg per os daily was administered. The follow-up period was 2 years. STATISTICAL ANALYSIS: Chi-square test and ANOVA were used for the analysis of data. RESULTS: There was a lower left globus pallidus regional cerebral blood flow in patients with better response. On the contrary, chronic patients were closer to normality. DISCUSSION: The results of the current study provide preliminary evidence concerning our ability to predict response to venlafaxine and to understand its way of action. |
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Authors:
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K N Fountoulakis; A Iacovides; M Karamouzis; G Gerasimou; Ph Grammatikos; F Fotiou; G Kaprinis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-10-16 |
Journal Detail:
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Title: Journal of affective disorders Volume: 99 ISSN: 0165-0327 ISO Abbreviation: J Affect Disord Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-02-26 Completed Date: 2007-06-14 Revised Date: 2009-09-28 |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 155-63 Citation Subset: IM |
Affiliation:
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Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thesssaloniki, Greece. kfount@med.auth.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antidepressive Agents / adverse effects, therapeutic use* Brain / drug effects, physiopathology Chronic Disease Cyclohexanols / adverse effects, therapeutic use* Depressive Disorder, Major / drug therapy*, physiopathology Dexamethasone / diagnostic use* Dexfenfluramine / diagnostic use* Dominance, Cerebral / physiology Electrooculography / drug effects Electroretinography / drug effects Evoked Potentials, Visual / drug effects, physiology* Female Follow-Up Studies Globus Pallidus / blood supply Humans Hydrocortisone / blood Male Middle Aged Prognosis Prolactin / blood* Recurrence Regional Blood Flow / drug effects, physiology Tomography, Emission-Computed, Single-Photon Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Cyclohexanols; 3239-44-9/Dexfenfluramine; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin; 93413-69-5/venlafaxine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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