Document Detail

Is it possible to predict the long-term response to venlafaxine with the use of biological markers and psychophysiological methods?
MedLine Citation:
PMID:  17049998     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The present study investigated whether it is possible to predict the medium term response to venlafaxine using biological markers and psychophysiological methods. MATERIAL: Fourteen (14) patients aged 21-60 years suffering from Major Depression according to DSM-IV were included in the study. METHODS: The SCAN v 2.0 and the IPDE were used to assist clinical diagnosis. Patients were investigated with electrooculogram (EOG), Pattern-Reversal Visual Evoked Potentials (PR-VEPs), Dexamethasone Suppression Test (DST), D-fenfluramine Challenge Test, and brain Single Photon Emission Tomography (SPECT). Venlafaxine 150-225 mg per os daily was administered. The follow-up period was 2 years. STATISTICAL ANALYSIS: Chi-square test and ANOVA were used for the analysis of data. RESULTS: There was a lower left globus pallidus regional cerebral blood flow in patients with better response. On the contrary, chronic patients were closer to normality. DISCUSSION: The results of the current study provide preliminary evidence concerning our ability to predict response to venlafaxine and to understand its way of action.
K N Fountoulakis; A Iacovides; M Karamouzis; G Gerasimou; Ph Grammatikos; F Fotiou; G Kaprinis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-16
Journal Detail:
Title:  Journal of affective disorders     Volume:  99     ISSN:  0165-0327     ISO Abbreviation:  J Affect Disord     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-02-26     Completed Date:  2007-06-14     Revised Date:  2009-09-28    
Medline Journal Info:
Nlm Unique ID:  7906073     Medline TA:  J Affect Disord     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  155-63     Citation Subset:  IM    
Laboratory of Psychophysiology, 3rd Department of Psychiatry, Aristotle University of Thesssaloniki, Greece.
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MeSH Terms
Antidepressive Agents / adverse effects,  therapeutic use*
Brain / drug effects,  physiopathology
Chronic Disease
Cyclohexanols / adverse effects,  therapeutic use*
Depressive Disorder, Major / drug therapy*,  physiopathology
Dexamethasone / diagnostic use*
Dexfenfluramine / diagnostic use*
Dominance, Cerebral / physiology
Electrooculography / drug effects
Electroretinography / drug effects
Evoked Potentials, Visual / drug effects,  physiology*
Follow-Up Studies
Globus Pallidus / blood supply
Hydrocortisone / blood
Middle Aged
Prolactin / blood*
Regional Blood Flow / drug effects,  physiology
Tomography, Emission-Computed, Single-Photon
Treatment Outcome
Reg. No./Substance:
0/Antidepressive Agents; 0/Cyclohexanols; 3239-44-9/Dexfenfluramine; 50-02-2/Dexamethasone; 50-23-7/Hydrocortisone; 9002-62-4/Prolactin; 93413-69-5/venlafaxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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