Document Detail


Is it possible to identify infrahissian cardiac conduction abnormalities in myotonic dystrophy by non-invasive methods?
MedLine Citation:
PMID:  10525524     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To identify intracardiac conduction abnormalities in patients with myotonic dystrophy from their clinical, ECG, and genetic features. METHODS: 39 consecutive patients (mean (SD) age 42. 9 (12.1) years; 16 female, 23 male) underwent clinical examination, genetic studies, resting and 24 hour ambulatory ECG, signal averaged ECG, and electrophysiological studies. RESULTS: 23 patients suffered from cardiac symptoms, 23 had one or more cardiac conduction abnormality on resting ECG, one had sinus deficiency, and 21 (53.8%) had prolonged HV intervals. No correlation was found between the severity of the neurological symptoms, onset of disease, cardiac conduction abnormalities on ECG, and the intracardiac conduction abnormalities on electrophysiological study. The size of the DNA mutation was longer in the abnormal HV interval group than in the normal HV interval group (3.5 (1.8) v 2.2 (1.0) kb, p < 0.02). Signal averaged ECG parameters (total QRS duration (QRSD) and duration of low amplitude signals </= 40 microV (LAS 40)) were greater in patients with an abnormal HV interval than in those with a normal HV interval (123.4 (24.6) v 102.8 (12.3) ms and 47.5 (12.8) v 35.3 (8.8) ms, respectively; p < 0.005). Only the association of QRSD >/= 100 ms with LAS 40 >/= 36 ms identified patients with an abnormal HV interval with good sensitivity (80%) and specificity (83. 3%). CONCLUSIONS: Infrahissian conduction abnormalities are common in myotonic dystrophy and can be identified using signal averaged electrocardiography.
Authors:
D Babuty; L Fauchier; D Tena-Carbi; P Poret; J Leche; M Raynaud; J P Fauchier; P Cosnay
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  82     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-23     Completed Date:  1999-12-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  634-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology B, Faculté de Médecine Tours, Hôpital Trousseau, 37044 Tours Cedex, France.
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MeSH Terms
Descriptor/Qualifier:
Adult
DNA Mutational Analysis
Electrocardiography
Female
Heart Conduction System / physiopathology*
Humans
Male
Middle Aged
Myotonic Dystrophy / genetics,  physiopathology*
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Comments/Corrections

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