Document Detail

Is it necessary to insert a nasobiliary drainage tube routinely after endoscopic clearance of the common bile duct in patients with choledocholithiasis-induced cholangitis? A prospective, randomized trial.
MedLine Citation:
PMID:  19913785     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Little is known about whether a routinely inserted endoscopic nasobiliary drainage (ENBD) tube improves the clinical course in patients with choledocholithiasis-induced acute cholangitis after clearance of choledocholithiasis. OBJECTIVE: The aim of this study was to investigate the need for ENBD on the clinical outcomes of patients with acute cholangitis undergoing endoscopic clearance of common bile duct (CBD) stones. DESIGN: Prospective, randomized study. SETTING: Tertiary referral center. PATIENTS: A total of 104 patients with choledocholithiasis-induced acute cholangitis who underwent primary endoscopic treatment were compared according to insertion of an ENBD tube (51 in the ENBD group and 53 in the no-ENBD group). INTERVENTION: Insertion of an ENBD tube after clearance of CBD stones. MAIN OUTCOME MEASUREMENTS: Recurrence of cholangitis and length of hospital stay after clearance of CBD stones. RESULTS: Baseline clinical characteristics were similar between both groups. There were no significant differences in the recurrence rate of cholangitis at 24 weeks (3.9% for the ENBD group vs 3.8% for the no-ENBD group at 24 weeks; P = .99) and length of hospital stay (7.9 days [standard error = 1.2] for the ENBD group vs 7.9 days [standard error = 0.7] for the no-ENBD group; P = .98). However, procedure time was longer (26.2 [SE = 1.8] minutes vs 22.7 [SE = 1.0] minutes, respectively; P = .01) and the discomfort score was higher (4.9 [SE = 0.4] vs 2.8 [SE = 0.3], respectively; P = .02) in the ENBD group than in the no-ENBD group. LIMITATIONS: Single-center study. CONCLUSIONS: A routinely inserted ENBD tube did not improve the clinical course, despite patients having to endure increased procedure time and discomfort, and the insertion would therefore be unnecessary.
Jun Kyu Lee; Sang Hyub Lee; Bong Kyun Kang; Jae Hak Kim; Moon-Soo Koh; Chang-Hun Yang; Jin Ho Lee
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-11-14
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  71     ISSN:  1097-6779     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-28     Completed Date:  2010-04-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  105-10     Citation Subset:  IM    
Copyright Information:
2010 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.
Department of Internal Medicine, Dongguk University International Hospital, Dongguk University College of Medicine, Goyang, Gyeonggi-do, Korea.
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MeSH Terms
Acute Disease
Cholangiopancreatography, Endoscopic Retrograde
Cholangitis / therapy*
Choledocholithiasis / complications,  therapy*
Drainage / methods*
Middle Aged
Prospective Studies

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