| The isolated perfused rat liver as an experimental model. | |
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MedLine Citation:
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PMID: 1524318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intrinsic liver function may be specifically studied using the isolated perfused liver system. In this report, the metabolic characteristics of the perfused rat liver are described in response to lactate (5 mM) and ammonia (10 mM) loading. These conditions are analogous to the increased substrate availability that accompanies some acute disease states such as trauma. Glucose production (490 +/- 85 nm/gm liver/min) was constant during a 90-minute perfusion whereas albumin secretion exhibited a biphasic kinetic profile in the absence of exogenous amino acids. Liver oxygen consumption (VO2) was responsive to substrate loading as evidenced by a 20 to 60 per cent initial increase in VO2. The authors conclude that a large portion of hepatic VO2 may normally be directed toward substrate clearance. Additionally, although hepatic secretory protein synthesis persists despite the limitation of nutrient amino acid supply, the kinetics of secretion are complex. |
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Authors:
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M S Dahn; R A Mitchell; E D Berberoglu; P Lange |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American surgeon Volume: 58 ISSN: 0003-1348 ISO Abbreviation: Am Surg Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-10-15 Completed Date: 1992-10-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370522 Medline TA: Am Surg Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 521-5; discussion 526 Citation Subset: IM |
Affiliation:
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Department of Surgery, Wayne State University, Detroit, Michigan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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pharmacokinetics,
secretion Amino Acids / physiology Ammonia / pharmacokinetics Animals Biological Availability Disease Models, Animal* Evaluation Studies as Topic Gluconeogenesis / drug effects Lactates / pharmacokinetics Lactic Acid Liver / drug effects, metabolism*, physiology Male Metabolic Clearance Rate Oxygen Consumption Perfusion / instrumentation, methods, standards* Rats Rats, Inbred Strains Urea / analysis, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Amino Acids; 0/Lactates; 50-21-5/Lactic Acid; 57-13-6/Urea; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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